Article

Massively parallel, computationally-guided design of a pro-enzyme

2021-03-26

Abstract excerpt

Confining the activity of a designed protein to a specific microenvironment would have broad-ranging applications, such as enabling cell type-specific therapeutic action by enzymes while avoiding off-target effects. While many natural enzymes are synthesized as inactive zymogens that can be activated by proteolysis, it has been challenging to re-design any chosen enzyme to be similarly stimulus-responsive. Here, w...

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Literature Corpus work: 10eeaec2-66b2-5077-aa1a-5c5cdf581eb2
DOI: 10.1101/2021.03.25.437042

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