Article

Synthesis based on covalent capture and release (SCCR): a programmable strategy for automated preparation of protease-activatable molecules

2026-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Enzyme-activatable chemical tools, including fluorogenic probes and prodrugs, are essential in chemical biology and targeted therapeutics but remain challenging to access in structurally diverse forms because their synthesis is often bespoke and difficult to standardize. Here, we introduce synthesis based on covalent capture and release (SCCR) as a programmable chemical strategy that enables the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c7d06549-71f9-57fc-abb3-d320aab8ad3b
DOI: 10.64898/2026.02.07.704608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synthesis based on covalent capture and release (SCCR): a programmable strategy for automated preparation of protease-activatable moleculesDOI 10.64898/2026.02.07.704608Read

Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral DrugsSemantic proximity Read

Reimagining proteome-wide evaluation of residue-specific bioconjugation chemistriesSemantic proximity Read

<i>De Novo</i> Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein BindersSemantic proximity Read

Engineering cathepsin S selective chemical probes and antibody-drug conjugates through substrate profiling with unnatural amino acidsSemantic proximity Read

Peptide-Drug Conjugates as Next-Generation Therapeutics: Exploring the Potential and Clinical ProgressSemantic proximity Read

Welding PROxAb Shuttles: A modular approach for generating bispecific antibodies via site-specific protein-protein conjugationSemantic proximity Read

RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates.Semantic proximity Read

Solid-Phase Synthesis of ProTide Fluorogenic Probes Enables Systematic Profiling of Carboxypeptidase ActivitySemantic proximity Read

High-throughput engineering and modification of non-ribosomal peptide synthetases based on Golden Gate assemblySemantic proximity Read

Affinity‐Directed Site‐Specific Protein Labeling and Its Application to Antibody‐Drug ConjugatesSemantic proximity Read

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.Semantic proximity Read

Controlled protein activities with viral proteases, antiviral peptides, and antiviral drugsSemantic proximity Read