Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease.

PloS one - 1 Jan 2014

Webster Carl I, Burrell Matthew, Olsson Lise-Lotte, Fowler Susan B, Digby Sarah, Sandercock Alan, Snijder Arjan, Tebbe Jan, Haupts Ulrich, Grudzinska Joanna, Jermutus Lutz, Andersson Christin

Abstract excerpt

Neprilysin is a transmembrane zinc metallopeptidase that degrades a wide range of peptide substrates. It has received attention as a potential therapy for Alzheimer's disease due to its ability to degrade the peptide amyloid beta. However, its broad range of peptide substrates has the potential to limit its therapeutic use due to degradation of additional peptides substrates that tightly regulate many...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neprilysin

Share to Peptide Fragments

Share to Peptides

Share to Protein Engineering

Share to Proteolysis

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 25089527
DOI: 10.1371/journal.pone.0104001
PMCID: PMC4121237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease.PMID 25089527Read ↗

Active site mutations change the cleavage specificity of neprilysin.Semantic proximity Read ↗

The neprilysin (NEP) family of zinc metalloendopeptidases: Genomics and functionSemantic proximity Read ↗

Neprilysin-2 Is an Important β-Amyloid Degrading EnzymeSemantic proximity Read ↗

De novo design of metalloproteases for targeted amyloid-β cleavageSemantic proximity Read ↗

Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.Semantic proximity Read ↗

The search for gamma-secretase and development of inhibitors.Semantic proximity Read ↗

The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity.Semantic proximity Read ↗

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseSemantic proximity Read ↗

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.Semantic proximity Read ↗

De novo designed protein inhibitors of amyloid aggregation and seedingSemantic proximity Read ↗

Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.Semantic proximity Read ↗

Biochemical Identification of the Neutral Endopeptidase Family Member Responsible for the Catabolism of Amyloid Peptide in the BrainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.