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Article

Insights into TREM2 biology by network analysis of human brain gene expression data.

Neurobiology of aging - 1 Dec 2013

Forabosco Paola, Ramasamy Adaikalavan, Trabzuni Daniah, Walker Robert, Smith Colin, Bras Jose, Levine Adam P, Hardy John, Pocock Jennifer M, Guerreiro Rita, Weale Michael E, Ryten Mina

Abstract excerpt

Rare variants in TREM2 cause susceptibility to late-onset Alzheimer's disease. Here we use microarray-based expression data generated from 101 neuropathologically normal individuals and covering 10 brain regions, including the hippocampus, to understand TREM2 biology in human brain. Using network analysis, we detect a highly preserved TREM2-containing module in human brain, show that it relates to microglia, and...

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Source

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Identifiers

PMID: 23855984
DOI: 10.1016/j.neurobiolaging.2013.05.001
PMCID: PMC3988951

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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