Article

mSWI/SNF interacts with the ribosome and its inhibition/mutations alter translation and sensitize to mTOR/PI3K inhibitors

2021-05-10

Abstract excerpt

The chromatin remodelers mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) subunits are mutated, deleted or amplified in more than 40% of cancers. Understanding their functions in normal cells and the consequences of cancer’s alterations will lead to path toward new targeted therapies. Canonically, mSWI/SNF complexes regulate the structure of chromatin, however they likely have additional functions which could b...

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Literature Corpus work: b9612a16-0fcb-5bb7-b6bd-66edaf54eccf
DOI: 10.1101/2021.05.10.443459

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