Article
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2012
Shain A Hunter, Giacomini Craig P, Matsukuma Karen, Karikari Collins A, Bashyam Murali D, Hidalgo Manuel, Maitra Anirban, Pollack Jonathan R
Abstract excerpt
Defining the molecular genetic alterations underlying pancreatic cancer may provide unique therapeutic insight for this deadly disease. Toward this goal, we report here an integrative DNA microarray and sequencing-based analysis of pancreatic cancer genomes. Notable among the alterations newly identified, genomic deletions, mutations, and rearrangements recurrently targeted genes encoding components of the...
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