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Article

Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.

The Biochemical journal - 1 Dec 2007

Gokool Suzanne, Tattersall Daniel, Reddy Jonathan V, Seaman Matthew N J

Abstract excerpt

The retromer complex is a conserved cytoplasmic coat complex that mediates the endosome-to-Golgi retrieval of vacuole/lysosome hydrolase receptors in yeast and mammals. The recognition of cargo proteins by the retromer is performed by the Vps35p/VPS35 (where Vps is vacuolar protein sorting) component, which together with Vps26p/VPS26 and Vps29p/VPS29, forms the cargo-selective subcomplex. In this report, we have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17696874
DOI: 10.1042/BJ20070555
PMCID: PMC2267345

Genes

VPS35
VPS29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.PMID 17696874Read ↗

Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.Semantic proximity Read ↗

Structural features of vps35p involved in interaction with other subunits of the retromer complex.Semantic proximity Read ↗

Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.Semantic proximity Read ↗

Mechanisms governing the endosomal membrane recruitment of the core retromer in Arabidopsis.Semantic proximity Read ↗

A mechanism for retromer endosomal coat complex assembly with cargo.Semantic proximity Read ↗

Arabidopsis VPS35, a retromer component, is required for vacuolar protein sorting and involved in plant growth and leaf senescence.Semantic proximity Read ↗

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.Semantic proximity Read ↗

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.Semantic proximity Read ↗

Vacuolar Protein Sorting 26C encodes an evolutionarily conserved large retromer subunit in eukaryotes that is important for root hair growth in Arabidopsis thaliana.Semantic proximity Read ↗

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.Semantic proximity Read ↗

The VPS35 protein and the role of its impairments in mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.Semantic proximity Read ↗

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