Back to search

Article

Astrocytes derived from ASD patients alter behavior and destabilize neuronal activity through aberrant Ca <sup>2+</sup> signaling

2021-10-12

Abstract excerpt

The cellular mechanisms of Autism Spectrum Disorder (ASD) are poorly understood. Cumulative evidence suggests that abnormal synapse function underlies many features of this disease. Astrocytes play in several key neuronal processes, including the formation of synapses and the modulation of synaptic plasticity. Astrocyte abnormalities have also been identified in the postmortem brain tissue of ASD patients. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b927e072-4c0f-5c29-92da-fdd13fbc836c
DOI
10.1101/2021.10.11.463231
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Astrocytes derived from ASD patients alter behavior and destabilize neuronal activity through aberrant Ca <sup>2+</sup> signalingDOI 10.1101/2021.10.11.463231
Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defectsSemantic proximity
Astrocytopathy Is Associated with CA1 Synaptic Dysfunction in a Mouse Model of Down SyndromeSemantic proximity
Activity of human-specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X SyndromeSemantic proximity
Astrocytes prevent abnormal neuronal development in the fragile x mouse.Semantic proximity
Astrocytic GABA transport controls fidelity of temporal processingSemantic proximity
Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate UptakeSemantic proximity
iAstrocytes model cytokine influences on complement expression and neuronal network synchronizationSemantic proximity
Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes.Semantic proximity
Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD.Semantic proximity
Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice.Semantic proximity
Chronic activation of astrocytic G <sub>q</sub> GPCR signaling has causal effects on visual LTP formation: implications for neurodegenerative diseasesSemantic proximity
Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human Down syndrome stem cell modelSemantic proximity
Select a neighboring publication to make it the new centre.