Article

Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defects

2024-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytes are emerging as key regulators of neuronal synaptic network maturation and function, through control of synaptic pruning. This is important, because individuals with ASD have excess glutamatergic synapses in the cortex, but the biological mechanisms underlying this phenotype remain unclear. Here, we used human cortical organoids (hCO) derived from induced pluripotent stem cells (hiPSC...

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Literature Corpus work: e1870cb0-e7b5-5cdc-a37e-4138204ede9c
DOI: 10.1101/2024.02.22.581651

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