Article

Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human Down syndrome stem cell model

2018-01-14

Abstract excerpt

Down syndrome (DS) is a devastating genetic disorder causing severe cognitive impairment. The staggering array of effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology. We developed an in vitro system to examine the interplay of neurons and astrocytes in a fully recapitulated HSA21 trisomy model differentiated from DS patient-derived induce...

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Literature Corpus work: 3b3edd66-af91-5857-8f5a-293a3a61af87
DOI: 10.1101/247585

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