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Article

Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD.

Molecular autism - 11 May 2020

Culotta Lorenza, Penzes Peter

Abstract excerpt

Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social interaction and communication, and repetitive or restricted behaviors. ASD subjects exhibit complex genetic and clinical heterogeneity, thus hindering the discovery of pathophysiological mechanisms. Considering that several ASD-risk genes encode proteins involved in the regulation of synaptic plasticity,...

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Identifiers

PMID: 32393347
DOI: 10.1186/s13229-020-00339-0
PMCID: PMC7216514

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