Article

Astrocytic GABA transport controls fidelity of temporal processing

2022-02-09

Abstract excerpt

Astrocytes control neural communications by influencing GABAergic transmission through uptake and synthesis of GABA. Impaired GABAergic signaling is thought to underlie cortical hyperexcitability in autism. Here we show that dysregulation of astrocyte GABA transport in Fragile X syndrome (FXS), a leading genetic cause of autism, contributes to circuit hyperexcitability. Human FXS astrocytes derived from patient-sp...

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Literature Corpus work: 8e9198dc-5287-5d24-a35c-ebbbc4a02e25
DOI: 10.1101/2022.02.08.479618

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