Article

iAstrocytes model cytokine influences on complement expression and neuronal network synchronization

2026-06-05

Abstract excerpt

Astrocytes play essential roles in neuronal development, function, and disease, yet existing methods to derive astrocytes from human pluripotent stem cells (hPSCs) are complex and can involve months of in vitro maturation. We developed a genomic safe-harbor knock-in system for inducible expression of the astrogenic transcription factors NFIA, NFIB, and SOX9, enabling rapid and robust generation of functional indu...

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Literature Corpus work: aa06c864-8ef0-5bd8-a386-f727a20a182c
DOI: 10.64898/2026.06.04.730242

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