Astrocytopathy Is Associated with CA1 Synaptic Dysfunction in a Mouse Model of Down Syndrome

Abstract excerpt

Brain pathophysiology in Down syndrome (DS), the most common genetic cause of intellectual disability, has traditionally been considered as a consequence of neuronal dysfunction. However, although it is well documented that astrocytes play a critical role in brain homeostasis, synaptic regulation, and neuronal support and their malfunction has been associated with the onset and progression of different neurologica...

Topics

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• Astrocytes
• Down syndrome and intellectual disability research
• Intellectual Disability
• Memory
• Neurodevelopmental Disorders
• Neurons
• Phenotype
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

5f9f8675-b85d-5bf0-879d-2ccba6f988c8

DOI

10.20944/preprints202506.1601.v1