Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice.

doi:10.1016/j.yexcr.2008.12.012

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Article

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice.

Experimental cell research - 15 Apr 2009

Cho Woosung, Messing Albee

Abstract excerpt

Alexander disease is a fatal leukoencephalopathy caused by dominantly-acting coding mutations in GFAP. Previous work has also implicated elevations in absolute levels of GFAP as central to the pathogenesis of the disease. However, identification of the critical astrocyte functions that are compromised by mis-expression of GFAP has not yet been possible. To provide new tools for investigating the nature of...

Topics

Alexander Disease
Animals
Astrocytes
Caspases
Cell Death
Cells, Cultured
Glial Fibrillary Acidic Protein
Humans
Hydrogen Peroxide
Mice
Mice, Transgenic
Mutation
Oxidants
Oxidative Stress
Proteasome Endopeptidase Complex
alpha-Crystallin B Chain

Source

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Identifiers

PMID: 19146851
DOI: 10.1016/j.yexcr.2008.12.012
PMCID: PMC2665202

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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