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Article

Design of the biosensor-dependent coupling system stabilizes the high-synthesis phenotype of cell factory.

Nature communications - 13 Apr 2026

Qin Lei, Yang Bo, Huang Rui, Zhang Haocheng, Li Qiuyang, Li Xinyi, Tan Yingqi, Sun Wentao, Jia Haiyang, Hu Bing, Lv Bo, Li Chun

Abstract excerpt

Microbial cell factories offer a sustainable route to plant-derived natural products, but yield drift and strain degeneration persist. Growth-coupled biosynthesis can continuously enrich high producers, yet specific product-responsive biosensors remain scarce and their population-level effects are unclear. Here, we describe a rapid transcriptome-mining workflow that, as proof-of-concept, delivers yeast biosensors...

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Identifiers

PMID: 41974726
DOI: 10.1038/s41467-026-71801-5
PMCID: PMC13247036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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