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Evolution-guided engineering of small-molecule biosensors

24 Oct 2019

Abstract excerpt

Allosteric transcription factors (aTFs) have proven widely applicable for biotechnology and synthetic biology as ligand-specific biosensors enabling real-time monitoring, selection and regulation of cellular metabolism. However, both the biosensor specificity and the correlation between ligand concentration and biosensor output signal, also known as the transfer function, often needs to be optimized before...

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PMID: 31777933
DOI: 10.1093/nar/gkz954

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