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Article

RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes.

Nature communications - 23 Aug 2017

Abatemarco Joseph, Sarhan Maen F, Wagner James M, Lin Jyun-Liang, Liu Leqian, Hassouneh Wafa, Yuan Shuo-Fu, Alper Hal S, Abate Adam R

Abstract excerpt

Synthetic biology and metabolic engineering seek to re-engineer microbes into "living foundries" for the production of high value chemicals. Through a "design-build-test" cycle paradigm, massive libraries of genetically engineered microbes can be constructed and tested for metabolite overproduction and secretion. However, library generation capacity outpaces the rate of high-throughput testing and screening. Well...

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Aptamers, Nucleotide
High-Throughput Screening Assays
Metabolic Engineering
Microfluidic Analytical Techniques
Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28835641
DOI: 10.1038/s41467-017-00425-7
PMCID: PMC5569033

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