Article

High-throughput kinetic analysis for target-directed covalent ligand discovery

2018-01-01

Abstract excerpt

Cysteine-reactive small molecules are used as chemical probes of biological systems and as medicines. By forming covalent bonds with target proteins they achieve distinct potency and selectivity profiles that are redefining the scope of potentially druggable targets. Identifying high-quality covalent ligands requires comprehensive kinetic analysis to distinguish selective binders from pan-reactive compounds. This...

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Literature Corpus work: 82019931-4ac7-50b1-b907-1fb4ad1d917a
DOI: 10.25560/66977

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