Article
Small-molecule binding sites to explore protein-protein interactions in the cancer proteome.
Molecular bioSystems - 20 Oct 2016
Xu David, Jalal Shadia I, Sledge George W, Meroueh Samy O
Abstract excerpt
The Cancer Genome Atlas (TCGA) offers an unprecedented opportunity to identify small-molecule binding sites on proteins with overexpressed mRNA levels that correlate with poor survival. Here, we analyze RNA-seq and clinical data for 10 tumor types to identify genes that are both overexpressed and correlate with patient survival. Protein products of these genes were scanned for binding sites that possess shape and...
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