Article

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

2023-10-23

Abstract excerpt

Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed DrugMap , an atlas of cysteine ligandability compiled across 416 cancer cell lines. We unexpectedly find that cysteine ligandability va...

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Literature Corpus work: ad44742d-62a7-584f-bd6e-6f4fecbd2def
DOI: 10.1101/2023.10.20.563287

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