Disruption of the KH1 domain of <i>Fmr1</i> leads to transcriptional alterations and attentional deficits in rats

Abstract excerpt

Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene. FXS is a leading monogenic cause of autism spectrum disorder (ASD) and inherited intellectual disability (ID). In most cases, the mutation is an expansion of a microsatellite (CGG triplet), which leads to suppressed expression of the fragile X mental retardation protein (FMRP), an RNA-binding protein involved in multip...

Topics

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• Behavior, Animal
• Disease Models, Animal
• Fragile X Mental Retardation Protein
• Fragile X Syndrome
• Hippocampus
• Mice
• Mutation, Missense
• Neuronal Plasticity

Identifiers and source

Literature Corpus work

58e0d452-46f0-5ed5-81f5-045c9f13bdec

DOI

10.1101/338988