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<i>Fmr1</i> KO causes delayed rebound spike timing in mediodorsal thalamocortical neurons through regulation of HCN channel activity

2025-02-03

Abstract excerpt

<h4>Background</h4> The neurodevelopmental disorder Fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene which prevents FMRP production. FMRP modulates the expression and function of a wide variety of proteins, including voltage-gated ion channels such as Hyperpolarization-Activated Cyclic Nucleotide gated (HCN) channels, which are integral to rhythmic activity in thalamic structures. Thalamoc...

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Literature Corpus work
5e314a7e-e16f-5b62-bf5c-8478028e03ce
DOI
10.1101/2025.02.02.636122
Open publication

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<i>Fmr1</i> KO causes delayed rebound spike timing in mediodorsal thalamocortical neurons through regulation of HCN channel activityDOI 10.1101/2025.02.02.636122
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