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A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of <i>Fmr1</i> KO mice and caused by loss of FMRP in cortical excitatory neurons

2025-03-19

Abstract excerpt

Predicting clinical therapeutic outcomes from preclinical animal studies remains an obstacle to developing treatments for neuropsychiatric disorders. Electrophysiological biomarkers analyzed consistently across species could bridge this divide. In humans, alpha oscillations in the resting state electroencephalogram (rsEEG) are altered in many disorders, but these disruptions have not yet been characterized in anim...

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Literature Corpus work
d1a44b13-784a-545a-8af9-23923970c477
DOI
10.1101/2025.03.19.644144
Open publication

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