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Schizophrenia-associated <i>NRXN1</i> deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids

2022-08-25

Abstract excerpt

De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a cell type-specific manner and disease background modulates these phenotypes. Here, we leveraged human pluripotent stem cell-derived forebrain organoid models carrying NRXN1 heterozygous deletions in isogenic and SCZ patient genetic back...

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Literature Corpus work
b87898f8-8599-51ec-b691-b91672b7e252
DOI
10.1101/2022.08.24.505165
Open publication

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Schizophrenia-associated <i>NRXN1</i> deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoidsDOI 10.1101/2022.08.24.505165
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