Article

Cell-type-resolved <i>NRXN1</i> isoforms in human brain and hiPSC cortical organoids

2025-11-12

Abstract excerpt

<h4>ABSTRACT</h4> NRXN1 undergoes extensive alternative splicing that generates a highly diverse repertoire of isoforms, diversifying protein–protein interactions, shaping synaptic specialization, and contributing to neuropsychiatric disease when disrupted. However, the splicing landscape of NRXN1 across distinct human brain cell types remains poorly defined. Because NRXN1 expression level is relatively low in...

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Literature Corpus work: 3daf5e6a-84f6-538b-a43a-8fd5f5d988da
DOI: 10.1101/2025.11.11.687875

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