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BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoids

2021-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Due to an inability to ethically access developing human brain tissue as well as identify prospective cases, early-arising neurodevelopmental and cell-specific signatures of Schizophrenia (Scz) have remained unknown and thus undefined. To overcome these challenges, we utilized Scz patient-derived stem cells to generate 3D cerebral organoids to model neuropathology of Scz during this critical per...

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Literature Corpus work
9e86f3e9-66ee-5c88-8b89-d53fe51529dd
DOI
10.1101/2021.06.10.447949
Open publication

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BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoidsDOI 10.1101/2021.06.10.447949
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