Article
Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling.
Schizophrenia research - 1 Nov 2024
Tordai Csongor, Hathy Edit, Gyergyák Hella, Vincze Katalin, Baradits Máté, Koller Júlia, Póti Ádám, Jezsó Bálint, Homolya László, Molnár Mária Judit, Nagy László, Szüts Dávid, Apáti Ágota, Réthelyi János M
Abstract excerpt
BACKGROUND: Schizophrenia (SCZ) is a severe neuropsychiatric disorder of complex, poorly understood etiology, associated with both genetic and environmental factors. De novo mutations (DNMs) represent a new source of genetic variation in SCZ, however, in most cases their biological significance remains unclear. We sought to investigate molecular disease pathways connected to DNMs in SCZ by combining human induced...
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