Article
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells.
Stem cells and development - 1 Sept 2020
De Los Angeles Alejandro, Tunbridge Elizabeth M
Abstract excerpt
Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in different clinical presentations, with variable penetrance, are unknown. To better understand the molecular and cellular consequences of heterozygous NRXN1 mutations, Flaherty and colleagues...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.