Article

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

2020-08-12

Abstract excerpt

The specificity of phosphorylation by protein kinases is essential to the integrity of biological signal transduction. While peptide sequence specificity for individual kinases has been examined previously, here we explore the evolutionary progression that has led to the modern substrate specificity of two non-receptor tyrosine kinases, Abl and Src. To efficiently determine the substrate specificity of modern and...

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Literature Corpus work: b85050b8-8703-5c73-b52a-6ef79d6e8402
DOI: 10.1101/2020.08.12.248104

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