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Article

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.

Critical reviews in biochemistry and molecular biology - 1 Oct 2018

Shah Neel H, Amacher Jeanine F, Nocka Laura M, Kuriyan John

Abstract excerpt

Tyrosine kinases were first discovered as the protein products of viral oncogenes. We now know that this large family of metazoan enzymes includes nearly one hundred structurally diverse members. Tyrosine kinases are broadly classified into two groups: the transmembrane receptor tyrosine kinases, which sense extracellular stimuli, and the cytoplasmic tyrosine kinases, which contain modular ligand-binding domains...

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Identifiers

PMID: 30183386
DOI: 10.1080/10409238.2018.1495173
PMCID: PMC6328253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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