Article
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
Nature - 9 Feb 1995
Songyang Z, Carraway K L, Eck M J, Harrison S C, Feldman R A, Mohammadi M, Schlessinger J, Hubbard S R, Smith D P, Eng C
Abstract excerpt
How do distinct protein-tyrosine kinases activate specific down-stream events? Src-homology-2 (SH2) domains on tyrosine kinases or targets of tyrosine kinases recognize phosphotyrosine in a specific sequence context and thereby provide some specificity. The role of the catalytic site of tyrosine...
Topics
- Amino Acid Sequence
- Animals
- Catalysis
- Cell Line
- Cytoplasm
- Drosophila Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Peptides
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases
- Signal Transduction
- Substrate Specificity