Article

De novo linear phosphorylation site motifs for BCR-ABL kinase revealed by phospho-proteomics in yeast

2022-12-05

Abstract excerpt

BCR-ABL is the oncogenic fusion product of tyrosine kinase ABL1 and a highly frequent driver of acute lymphocytic leukemia (ALL) and chronic myeloid leukemia (CML). The kinase activity of BCR-ABL is strongly elevated, however changes of substrate specificity in comparison to wild-type ABL1 kinase are less well characterized. Here, we heterologously expressed full-length BCR-ABL kinases in yeast. We exploited the p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51caa331-00c2-5672-a02e-b5c15fea2881
DOI: 10.1101/2022.12.05.519126

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

De novo linear phosphorylation site motifs for BCR-ABL kinase revealed by phospho-proteomics in yeastDOI 10.1101/2022.12.05.519126Read

Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomicsSemantic proximity Read

A common phosphotyrosine signature for the Bcr-Abl kinaseSemantic proximity Read

Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targetsSemantic proximity Read

Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategiesSemantic proximity Read

Detection of a rare BCR–ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS)Semantic proximity Read

A novel peptide biosensor for screening ABL1 activity in vitro: a challenge for precision therapy in BCR-ABL1 and BCR-ABL1 like leukemias.Semantic proximity Read

Mining the tumor phosphoproteome for cancer markers.Semantic proximity Read

Charting the molecular network of the drug target Bcr-AblSemantic proximity Read

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate poolSemantic proximity Read

Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA).Semantic proximity Read

Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines.Semantic proximity Read

Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL.Semantic proximity Read