Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The capable ABL: what is its biological function?

Molecular and cellular biology - 1 Apr 2014

Wang Jean Y J

Abstract excerpt

The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative stress, and other signals, ABL is activated to stimulate cell proliferation or differentiation, survival or death, retraction, or migration. ABL also regulates specialized functions such as antigen receptor signaling in lymphocytes, synapse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Biological
Share to Genes, abl
Share to Nuclear Localization Signals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Kinase Inhibitors

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-abl

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 24421390
DOI: 10.1128/MCB.01454-13
PMCID: PMC3993570

Genes

ABL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The capable ABL: what is its biological function?PMID 24421390Read ↗

Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.Semantic proximity Read ↗

Structure, Regulation, Signaling, and Targeting of Abl Kinases in CancerSemantic proximity Read ↗

Crk and Abi1: Binary Molecular Switches That Regulate Abl Tyrosine Kinase and Signaling to the CytoskeletonSemantic proximity Read ↗

Structure and dynamic regulation of Abl kinases.Semantic proximity Read ↗

The Role of c-Abl Tyrosine Kinase in Brain and Its PathologiesSemantic proximity Read ↗

Activated Abl kinase inhibits oncogenic transforming growth factor‐β signaling and tumorigenesis in mammary tumorsSemantic proximity Read ↗

Roles for c-Abl in postoperative neurodegenerationSemantic proximity Read ↗

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate poolSemantic proximity Read ↗

Emerging roles of pseudokinases.Semantic proximity Read ↗

A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization.Semantic proximity Read ↗

The impact of the BCR-ABL oncogene in the pathology and treatment of chronic myeloid leukemiaSemantic proximity Read ↗

Pathogenic variants causing ABL1 malformation syndrome cluster in a myristoyl-binding pocket and increase tyrosine kinase activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.