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Article

Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism.

Science (New York, N.Y.) - 20 Feb 2015

Wilson C, Agafonov R V, Hoemberger M, Kutter S, Zorba A, Halpin J, Buosi V, Otten R, Waterman D, Theobald D L, Kern D

Abstract excerpt

Macromolecular function is rooted in energy landscapes, where sequence determines not a single structure but an ensemble of conformations. Hence, evolution modifies a protein's function by altering its energy landscape. Here, we recreate the evolutionary pathway between two modern human oncogenes, Src and Abl, by reconstructing their common ancestors. Our evolutionary reconstruction combined with x-ray structures...

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Identifiers

PMID: 25700521
DOI: 10.1126/science.aaa1823
PMCID: PMC4405104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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