Article

NSun2 deficiency promotes tau hyperphosphorylation and neurodegeneration through epitranscriptomic regulation of miR-125b

2021-06-16

Abstract excerpt

Overproduction or suppression of certain microRNAs (miRNAs) in Alzheimer’s disease (AD) brains promote alterations in tau proteostasis and neurodegeneration. However, the mechanisms governing how specific miRNAs are dysregulated in AD brains are still under investigation. Epitranscriptomic regulation adds a layer of post-transcriptional control to brain function during development and adulthood. NOP2/Sun RNA methy...

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Literature Corpus work: b841ef76-2103-5e3a-bf2e-d976200383ce
DOI: 10.1101/2021.06.16.448614

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