Article

The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neurons

2025-04-15

Abstract excerpt

The degradation of aggregation-prone tau is regulated by the ubiquitin-proteasome system (UPS) and autophagy, which are impaired in Alzheimer’s disease (AD) and related tauopathies causing tau aggregation. Protein ubiquitination with linkage specificity determines the fate of proteins that can be either degradative or stabilization signals. While the linear M1-linked ubiquitination on protein aggregates is a signa...

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Literature Corpus work: bafa8b71-c538-5b6c-8523-54a58f0390b9
DOI: 10.1101/2025.04.09.648063

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