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<i>HnRNPAB</i> -targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimer’s disease-associated alternative splicing

2026-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant alternative splicing alters multiple disease-associated splicing events, including MAPT exon 10 inclusion linked to tau pathology, and thereby impacts Alzheimer’s disease (AD) progression. Heterogeneous nuclear ribonucleoprotein AB (hnRNPAB) functions as a splicing regulator, yet its roles in AD remain poorly defined. Here, we identified AB332, the full-length isoform of hnRNPAB, as a n...

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Literature Corpus work
10c736c1-9220-58e6-809d-49898f69fea3
DOI
10.64898/2026.07.02.736008
Open publication

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<i>HnRNPAB</i> -targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimer’s disease-associated alternative splicingDOI 10.64898/2026.07.02.736008
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