Article

Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment

2023-10-10

Abstract excerpt

The toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na + channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action potential (AP), a functional analysis of the effect of the toxin in the axon initial segment (AIS), where VGNCs are highly expressed, was never performed so far. Here, we rep...

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Literature Corpus work: b82fbfba-ee2e-5870-a526-b55c2325b2a8
DOI: 10.1101/2023.10.06.561226

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