Article

Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders

2021-07-29

Abstract excerpt

The 20–60-μm axon initial segment (AIS) is proximally located at the interface between the axon and cell body. AIS has characteristic molecular and structural properties regulated by the crucial protein, ankyrin-G. The AIS contains a high density of Na+ channels relative to the cell body, which allows low thresholds for initiation of action potential (AP). Molecular and physiological studies have shown th...

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Literature Corpus work: f82fad58-3546-5e4a-8b41-7808d3369094
DOI: 10.20944/preprints202107.0671.v1

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