Article

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

2022-06-12

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Voltage-gated sodium channels (Nav) are essential for the initiation and propagation of action potentials in neurons. Of the different channel subtypes, Nav1.1, Nav1.2 and Nav1.6 are prominently expressed in the adult central nervous system (CNS). All three of these sodium channel subtypes are sensitive to block by the neurotoxin tetrodotoxin (TTX), with TTX being almost equipotent on all three subtypes. In the pr...

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Literature Corpus work: f62f684d-693d-5b39-bf55-372c82e4b62b
DOI: 10.1101/2022.06.08.494063

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Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and <i>ex vivo</i> seizures

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