Article

Axon Initial Segment Pathology in Alzheimer's Disease Mouse Model Disturbs the Action Potential Initiation and Propagation

2021-10-20

Abstract excerpt

Axonal pathology has been widely reported in Alzheimer’s disease (AD). As a highly structured region in the axon, axon initial segment (AIS) plays a vital role in action potential (AP) dynamics, including initiation and propagation, closely linked to neuronal excitability and neurotransmitter release kinetics. Previously, we showed that proteins localized in the AIS were remarkably changed in neurons from APP swe...

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Literature Corpus work: 0a43975b-8fb6-5959-8ca4-68fad6bf7d2e
DOI: 10.21203/rs.3.rs-929763/v1

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