Article

A Review of Systems Biology of Axon Initial Segment: Action Potential Initiation, Propagation, and Neurological Diseases

2024-10-11

Abstract excerpt

The axon initial segment (AIS) region is crucial for action potential (AP) initiation due to its molecular organization especially voltage gated ion channels and Ankyrin-G (AnkG). AnkG act as recruiter and restrict almost all the proteins at AIS in order to maintain the AIS assembly. Voltage gated sodium channels (Nav channels) are enriched at AIS with high density and independently responsible for the AP initiati...

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Literature Corpus work: 26ab8514-c5ce-58bd-88a4-32ed48f56c39
DOI: 10.20944/preprints202410.0878.v1

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