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Article

Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization

13 Feb 2017

Abstract excerpt

Although action potentials propagate along axons in an all-or-none manner, subthreshold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic boutons. An important mechanism underlying analog-digital modulation is depolarization-mediated inactivation of presynaptic Kv1-family potassium channels, leading to action potential broadening and increased calcium influx. Previous...

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PMID: 28193892
DOI: 10.1073/pnas.1608763114

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