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Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease

14 Oct 2024

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid-β (Aβ) and hyperphosphorylated tau. Identifying the neuropathological changes preceding cognitive decline is crucial for early intervention. Axon initial segment (AIS) maintains the orderly structure of the axon and is responsible for initiating action potentials (APs). To investigate the role...

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PMID: 39415847
DOI: 10.1002/mco2.768

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