Article

Late I <sub>Na</sub> activation of cardiac TTX-sensitive sodium channels by AaH-II induces an arrhythmogenic phenotype

2025-09-20

Abstract excerpt

<h4>Aims</h4> Late sodium current (I NaL ) is a key contributor to cardiac arrhythmias, but its precise origin and arrhythmogenic potential from tetrodotoxin-sensitive (TTX-S) sodium (Na v ) channels remain unclear. While the FDA-endorsed toxin ATX-II has been widely used to model I NaL -associated arrhythmogenesis, it lacks selectivity, limiting its utility in dissecting the roles of individual Na v channel...

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Literature Corpus work: f6fae320-0e08-5360-8c80-4b357a30d480
DOI: 10.1101/2025.09.17.676709

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