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Article

Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders.

Cells - 17 Aug 2021

Fujitani Masashi, Otani Yoshinori, Miyajima Hisao

Abstract excerpt

The 20-60 μm axon initial segment (AIS) is proximally located at the interface between the axon and cell body. AIS has characteristic molecular and structural properties regulated by the crucial protein, ankyrin-G. The AIS contains a high density of Na+ channels relative to the cell body, which allows low thresholds for the initiation of action potential (AP). Molecular and physiological studies have shown that...

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Identifiers

PMID: 34440880
DOI: 10.3390/cells10082110
PMCID: PMC8392614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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