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Article

Axon initial segments: structure, function, and disease

1 May 2018

Abstract excerpt

The axon initial segment (AIS) is located at the proximal axon and is the site of action potential initiation. This reflects the high density of ion channels found at the AIS. Adaptive changes to the location and length of the AIS can fine-tune the excitability of neurons and modulate plasticity in response to activity. The AIS plays an important role in maintaining neuronal polarity by regulating the trafficking...

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PMID: 29749636
DOI: 10.1111/nyas.13718

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