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Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum

2017-10-27

Abstract excerpt

The unfolded protein response (UPR) is an evolutionarily conserved stress response to intra- and extracellular conditions that disrupt endoplasmic reticulum (ER) protein-folding capacity. The UPR is engaged by a variety of disease conditions, including most cancers as well as both metabolic and neurodegenerative disorders. Three transmembrane transducers—PERK, IRE1, and ATF6—are responsible for activating downstre...

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Literature Corpus work
b8294d0b-2ad1-52a3-9584-7ed0f56001c9
DOI
10.12688/f1000research.12138.1
Open publication

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