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Article

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

18 Dec 2015

Abstract excerpt

The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads to cell death. This time-dependent dual functionality of the UPR represents the adaptive and cytotoxic pathways that result from ER stress. Chronic UPR activation in systemic and neurodegenerative diseases has been identified as an...

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PMID: 26679859
DOI: 10.2174/1567205013666151218145431

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